Canine Degenerative Myelopathy

A dog with degenerative myelopathy often stands with its legs close together and may not correct an unusual foot position due to a lack of conscious proprioception

Canine degenerative myelopathy, also known as chronic degenerative radiculomyelopathy, is an incurable, progressive disease of the canine spinal cord that is similar in many ways to amyotrophic lateral sclerosis. Onset is typically after the age of 7 years and it is seen most frequently in the German shepherd dog, Pembroke Welsh corgi, and boxer dog, though the disorder is strongly associated with a gene mutation in SOD1 that has been found in 43 breeds as of 2008, including the wire fox terrier, Chesapeake Bay retriever, Rhodesian ridgeback, and Cardigan Welsh corgi.[1][2] Progressive weakness and incoordination of the rear limbs are often the first signs seen in affected dogs, with progression over time to complete paralysis. Myelin is an insulating sheath around neurons in the spinal cord. One proposed cause of degenerative myelopathy is that the immune system attacks this sheath, breaking it down. This results in a loss of communication between nerves in lower body of the animal and the brain.

Contents:

• 1 Testing
• 2 Genetics
• 3 Symptoms
• 4 Causes
• 5 Treatment
• 5.1 Exercise

Testing: The Orthopedic Foundation for Animals has a DNA saliva test to screen for the mutated gene that has been seen in dogs with degenerative myelopathy. Now that a test is available the disease can be bred out of breeds with a high preponderance. The test is only recommended for predisposed breeds, but can be performed on DNA from any dog on samples collected through swabbing the inside of the animal's cheek with a sterile cotton swab or through venipuncture.

The test determines whether the mutated copy of SOD1 is present in the DNA sample submitted. It must be interpreted with caution by a veterinary clinician in combination with the animal's clinical signs and other lab test results.

The results reported are:

• Normal / Normal (N/N, or 'clear'): The dog does not have the mutation and is extremely unlikely to develop degenerative myelopathy. There have been cases in which dogs that tested clear were found to have DM upon necropsy. This information was given to Dr Keller from the OFA. Dr Coates performed necropsy. It is important to note the OFA statement on their website that states "Recent evidence suggest that there are other causes of DM in some breeds".
• Normal / Abnormal (N/A or 'carrier'): The dog has one mutated copy of the gene (is heterozygous) and is a carrier but will not have degenerative myelopathy though there has now been several cases of Carriers developing DM. It will be possible for it to pass the mutation to offspring. A thorough examination of the dog's pedigree and DNA testing should be undertaken prior to breeding a dog with this result.
• Abnormal / Abnormal (A/A or 'At Risk'): The dog has two copies (is homozygous) for the mutation and is at risk for degenerative myelopathy.

• If both parents are clear (N/N) then all of the puppies will be clear
• If one parent is a carrier (N/A) and one is clear (N/N) then roughly 50% of the puppies will be clear and 50% will be carriers
• If both parents are carriers (N/A) then roughly 25% will be clear (N/N), 50% will be carriers (N/A), and 25% will be At risk (A/A)
• If one parent is clear (N/N) and one parent is affected (A/A) then all puppies will be carriers (N/A)
• If one parent is a carrier (N/A) and one is at risk (A/A) then roughly 50% of the puppies will be carriers (N/A) and 50% will be At risk (A/A)
• If both parents are At risk (A/A) then all puppies will be At risk (A/A)

Progression of the disease is generally slow but highly variable. The animal could be crippled within a few months, or may survive as long as three years or more.

Causes: The etiology of this disease is unknown. Recent research has shown that a mutation in the SOD1 gene is a risk factor for developing degnerative myelopathy in several breeds. Mutations in SOD1 are also associated with familial amyotrophic lateral sclerosis (Lou Gehrig's disease) in people. Known causes of spinal cord dysfunction should be excluded before accepting the diagnosis of degenerative myelopathy; disc disease (protrusions) or spinal cord tumors can cause compression of the spinal cord with similar signs to degenerative myelopathy.

Treatment: Degenerative myelopathy is an irreversible, progressive disease that cannot be cured. There are no treatments that have been clearly shown to stop or slow progression of DM.

Exercise: Exercise has been recommended to maintain the dog's ability to walk. Physiotherapy may prolong the length of time that the dog remains mobile and increase survival time. Canine hydrotherapy (swimming) may be more useful than walking. Use of a belly sling or hand-held harness allows the handler the ability to support the dog's hind legs for exercising or going up and down stairs.A 2-wheel dog cart, or "dog wheelchair" can allow the dog to remain active and maintain its quality of life once signs of weakness or paralysis of the hind limbs is detected.